The CD300A Polyclonal Antibody (PAC020168) is a valuable tool for researchers studying the role of CD300A in immune regulation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the CD300A protein, this antibody allows for the detection and analysis of CD300A in various cell types, making it a versatile tool for studies in immunology and cancer research.CD300A, also known as an immune inhibitory receptor, plays a crucial role in maintaining immune homeostasis by regulating inflammation and inhibiting allergic reactions.
Its involvement in immune response modulation makes it a promising target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CD300A is essential for the development of therapies that can either enhance or suppress immune responses in these disease contexts.Overall, the CD300A Polyclonal Antibody (PAC020168) offers researchers a reliable and specific tool for studying CD300A in various experimental settings, contributing to a better understanding of immune regulation and its implications in disease pathogenesis.
Antibody Name:
PAGE4 Antibody (PACO20168)
Antibody SKU:
PACO20168
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PAGE4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20168(PAGE4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens.
Synonyms:
P antigen family, member 4
UniProt Protein Function:
PAGE4: a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. strongly expressed in prostate and prostate cancer, but is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]Protein type: Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: Xp11.23
UniProt Protein Details:
NCBI Summary:
This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. [provided by RefSeq, Aug 2013]
