The PADI2 Polyclonal Antibody (CAB12236) is a valuable tool for researchers studying PADI2, a key enzyme involved in post-translational protein citrullination. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to PADI2, researchers can effectively detect and analyze the enzyme in a variety of cell types, making it an essential reagent for studies in rheumatology, cancer, and neurology.PADI2, also known as peptidylarginine deiminase 2, plays a crucial role in modulating protein function through citrullination, a process that affects protein structure and function.
Dysregulation of PADI2 activity has been implicated in various diseases, including rheumatoid arthritis and certain cancers, making it a promising target for therapeutic intervention. Understanding the role of PADI2 in disease pathogenesis is essential for the development of novel treatments that target this enzyme.Overall, the PADI2 Polyclonal Antibody serves as a powerful tool for researchers seeking to elucidate the functions of PADI2 in health and disease. Its high specificity and reactivity make it an indispensable resource for advancing our understanding of the molecular mechanisms underlying various pathological conditions.
Product Name:
PADI2 Rabbit Polyclonal Antibody
SKU:
CAB12236
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PADI2 (NP_031391.2).
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
Purification Method:
Affinity purification
Gene ID:
11240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PADI2 Rabbit pAb (CAB12236) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
