PADI2 Rabbit Polyclonal Antibody (CAB12236)
- SKU:
- CAB12236
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PADI2 Rabbit Polyclonal Antibody |
SKU: | CAB12236 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PADI2 (NP_031391.2). |
Sequence: | MLRE RTVR LQYG SRVE AVYV LGTY LWTD VYSA APAG AQTF SLKH SEHV WVEV VRDG EAEE VATN GKQR WLLS PSTT LRVT MSQA STEA SSDK VTVN YYDE EGSI PIDQ AGLF LTAI EISL DVDA DRDG VVEK NNPK KASW TWGP EGQG AILL VNCD RETP WLPK EDCR DEKV YSKE DLKD MSQM ILRT KGPD RLPA GYEI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PAD2; PDI2; PAD-H19; PADI2 |
Positive Sample: | U-87MG,HT-29,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 76kDa |
Observed MW: | 75kDa |
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
Purification Method: | Affinity purification |
Gene ID: | 11240 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |