The PADI2 Polyclonal Antibody (CAB11711) is a valuable tool for researchers studying PADI2, an enzyme involved in post-translational modification of proteins through citrullination. This antibody is raised in rabbits and has high reactivity with human samples, making it suitable for Western blot applications.PADI2, also known as peptidyl arginine deiminase 2, plays a critical role in various biological processes, including gene regulation, immune response, and inflammation. Dysregulation of PADI2 has been implicated in autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, as well as in cancer progression.
By targeting the PADI2 protein, researchers can gain insights into the mechanisms underlying disease pathology and potentially identify novel therapeutic targets. The PADI2 Polyclonal Antibody is a valuable tool for investigating the function of PADI2 in different cell types and tissues, advancing our understanding of disease mechanisms and potential treatment strategies.
Product Name:
PADI2 Rabbit Polyclonal Antibody
SKU:
CAB11711
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-210 of human PADI2 (NP_031391.2).
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
Purification Method:
Affinity purification
Gene ID:
11240
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PADI2 Rabbit pAb (CAB11711) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
