The PACRG Polyclonal Antibody (CAB15956) is a valuable tool for researchers studying PACRG, a protein associated with cilia function and neurodevelopmental disorders. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PACRG protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for research in the fields of neuroscience and developmental biology.PACRG is known for its involvement in cilia-related processes, playing a crucial role in maintaining proper ciliary function and cellular transport mechanisms.
Mutations in the PACRG gene have been linked to neurodevelopmental disorders, making it a key target for investigating the mechanisms underlying these conditions. By studying the function of PACRG, researchers can gain insights into the pathophysiology of various neurodevelopmental disorders and potentially identify new therapeutic targets for intervention.Overall, the PACRG Polyclonal Antibody (CAB15956) provides researchers with a reliable tool for studying the role of PACRG in cilia function and neurodevelopmental disorders. Its high specificity and reactivity make it an essential resource for advancing our understanding of these complex biological processes.
Product Name:
PACRG Rabbit Polyclonal Antibody
SKU:
CAB15956
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PACRG (NP_001073847.1).
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
135138
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PACRG Rabbit pAb (CAB15956) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
