PABPN1 Rabbit Monoclonal Antibody (CAB1735)
- SKU:
- CAB1735
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | PABPN1 Rabbit Monoclonal Antibody |
SKU: | CAB1735 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (Q86U42). |
Sequence: | MAAA AAAA AAAG AAGG RGSG PGRR RHLV PGAG GEAG EGAP GGAG DYGN GLES EELE PEEL LLEP EPEP EPEE EPPR PRAP PGAP GPGP GSGA PGSQ EEEE |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | OPMD; PAB2; PABII; PABP2; PABP-2; PABPN1 |
Positive Sample: | HeLa,HepG2,Raji,Mouse lung,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 31kDa/33kDa |
Observed MW: | 50kDa |
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
Purification Method: | Affinity purification |
Gene ID: | 8106 |
Clone Number: | ARC0730 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |