The PABPC5 Polyclonal Antibody (CAB9997) is a valuable tool for researchers studying PABPC5, a key protein involved in mRNA translation and stability. This antibody, produced in rabbits, is highly specific to human samples and is optimized for use in Western blot applications. By targeting the PABPC5 protein, this antibody allows for the precise detection and analysis of PABPC5 levels in various cell types, making it ideal for studies in molecular biology and RNA regulation.PABPC5, also known as Poly(A)-binding protein 5, plays a crucial role in post-transcriptional control of gene expression by binding to the poly(A) tail of mRNA molecules.
Its involvement in mRNA stability and translation makes it a significant target for research in areas such as gene regulation, RNA processing, and protein synthesis. Understanding the functions of PABPC5 is essential for exploring its potential implications in diseases like cancer, neurodegenerative disorders, and developmental abnormalities. By utilizing the PABPC5 Polyclonal Antibody, researchers can further unravel the complex mechanisms underlying mRNA regulation and potentially identify new therapeutic targets.
Product Name:
PABPC5 Rabbit Polyclonal Antibody
SKU:
CAB9997
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PABPC5 (NP_543022.1).
This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder.
Purification Method:
Affinity purification
Gene ID:
140886
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PABPC5 antibody (CAB9997) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
