The PABPC1 Polyclonal Antibody (CAB14872) is a valuable tool for researchers studying PABPC1, a key protein involved in post-transcriptional regulation of gene expression. This antibody, produced using rabbits, is highly specific for human samples and has been validated for use in Western blotting applications.PABPC1, also known as poly(A)-binding protein cytoplasmic 1, plays a crucial role in mRNA stability and translation efficiency. Dysregulation of PABPC1 has been linked to various diseases, including cancer, neurodegenerative disorders, and viral infections.
By targeting PABPC1, researchers can investigate its role in these conditions and potentially uncover new therapeutic targets.The PABPC1 Polyclonal Antibody enables the detection and analysis of PABPC1 in different cell types, making it ideal for studies in molecular biology, oncology, and virology. Understanding the functions of PABPC1 can provide valuable insights into cellular processes and disease mechanisms, ultimately leading to the development of novel treatments and interventions.
Product Name:
pAbPC1 Rabbit Polyclonal Antibody
SKU:
CAB14872
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human PABPC1 (NP_002559.2).
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.
Purification Method:
Affinity purification
Gene ID:
26986
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using pAbPC1 Rabbit pAb (CAB14872) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
