The P4HA2 Monoclonal Antibody is a valuable tool for researchers studying P4HA2, an enzyme involved in the production of collagen and the maintenance of extracellular matrix integrity. This monoclonal antibody, produced using advanced technology, specifically targets P4HA2 in human samples and is suitable for use in various research applications, including immunohistochemistry and flow cytometry.P4HA2 plays a crucial role in the regulation of collagen synthesis, which is essential for tissue remodeling, wound healing, and tumor progression. By targeting P4HA2, researchers can gain insights into its functions and potential therapeutic implications in diseases such as cancer, fibrosis, and tissue fibrosis.
With its high specificity and sensitivity, the P4HA2 Monoclonal Antibody is a valuable addition to the arsenal of tools available for investigating the role of P4HA2 in health and disease. Researchers can utilize this antibody to explore the mechanisms underlying collagen synthesis and extracellular matrix remodeling, paving the way for the development of novel therapeutic strategies targeting P4HA2.
Product Name:
P4HA2 Monoclonal Antibody
SKU:
CAB22150
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 157-333 of human P4HA2 (NP_004190.1).
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
8974
Clone Number:
ARC54912
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using P4HA2 antibody (CAB22150) at1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
