The p38 MAPK Rabbit Monoclonal Antibody (CAB4771) is a powerful tool for researchers studying the p38 mitogen-activated protein kinase (MAPK) signaling pathway, which plays a crucial role in cellular responses to stress and inflammation. This high-quality antibody, raised in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.The p38 MAPK pathway is involved in a wide range of cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of this pathway has been implicated in various diseases, including cancer, inflammatory disorders, and neurodegenerative conditions.
By targeting the p38 MAPK protein, researchers can gain valuable insights into how this pathway contributes to disease progression and potentially identify new therapeutic targets.With its ability to detect and analyze p38 MAPK protein expression in different cell types, the CAB4771 antibody is an essential tool for studies in cell signaling, drug development, and disease mechanisms. By using this antibody, researchers can further our understanding of the p38 MAPK pathway and potentially uncover novel strategies for treating diseases associated with its dysregulation.
Product Name:
p38 MAPK Rabbit Monoclonal Antibody
SKU:
CAB4771
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human p38 MAPK (Q16539).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
1432
Clone Number:
ARC0201
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using p38 MAPK Rabbit mAb (CAB4771) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min.
