The P2Y Purinoceptor 14 Polyclonal Antibody (CAB8178) is specifically designed for research involving the P2Y purinoceptor 14 protein, a cell surface receptor involved in purinergic signaling pathways. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.The P2Y purinoceptor 14 protein plays a crucial role in mediating cellular responses to extracellular nucleotides, including ATP and ADP, which are important signaling molecules in processes such as inflammation, neurotransmission, and thrombosis. By targeting this receptor, researchers can gain insights into the regulation of these physiological processes and explore its implications in diseases such as cardiovascular disorders, neurodegenerative diseases, and immune disorders.
With its high specificity and sensitivity, the P2Y Purinoceptor 14 Polyclonal Antibody (CAB8178) is an essential tool for studying the function and regulation of P2Y purinoceptor 14 in various cell types and tissues. Its utility in both basic research and drug discovery makes it a valuable resource for scientists investigating purinergic signaling pathways and their therapeutic potential.
Product Name:
P2RY14 Rabbit Polyclonal Antibody
SKU:
CAB8178
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 209-338 of human P2RY14 (NP_055694.3).
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
9934
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using P2RY14 Rabbit pAb (CAB8178) at 1:1500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
