The P2X Purinoceptor 4 Polyclonal Antibody (CAB6682) is a valuable tool for researchers studying the P2X receptor family, specifically P2X4. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the P2X4 receptor protein, this antibody enables the detection and analysis of P2X4 in various cell types, making it an ideal choice for studies in neuroscience, pharmacology, and immunology.P2X4 is a member of the P2X receptor family, which are ligand-gated ion channels activated by extracellular ATP.
P2X4 is known to play a role in various physiological processes, including synaptic transmission, pain sensation, and immune responses. Research on P2X4 has implications for the development of therapeutics targeting pain management, neurodegenerative diseases, and inflammatory disorders. Therefore, understanding the function and regulation of P2X4 is essential for advancing our knowledge in these areas and ultimately improving patient outcomes.
Product Name:
P2RX4 Rabbit Polyclonal Antibody
SKU:
CAB6682
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 55-338 of human P2RX4 (NP_002551.2).
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5025
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using P2RX4 antibody (CAB6682) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
