The P2RY12 Polyclonal Antibody (CAB1710) is a research tool designed for studying the P2RY12 receptor, a key regulator of platelet activation and aggregation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the P2RY12 protein, researchers can detect and analyze its expression in various cell types, making it a valuable tool for studies in cardiovascular biology and hemostasis.
P2RY12 is a G-protein coupled receptor that plays a crucial role in mediating platelet activation in response to ADP (adenosine diphosphate). Dysregulation of P2RY12 signaling has been implicated in various thrombotic disorders, making it a potential target for the development of antiplatelet therapies. Understanding the function of P2RY12 is essential for advancing our knowledge of platelet biology and developing strategies to treat thrombotic diseases effectively.
Product Name:
P2RY12 Rabbit Polyclonal Antibody
SKU:
CAB1710
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 243-342 of human P2RY12 (NP_795345.1).
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
64805
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse brain using P2RY12 Rabbit pAb(CAB1710) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:45s.
