The P2X purinoceptor 7 Polyclonal Antibody (CAB10511) is a valuable tool for researchers studying P2X purinoceptor 7, a receptor involved in mediating immune responses and inflammatory processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the P2X purinoceptor 7 protein, this antibody enables accurate detection and analysis in various cell types, making it a versatile option for studies in immunology, inflammation, and related fields.P2X purinoceptor 7, also known as P2X7 receptor, is a key player in the immune system, regulating inflammatory responses and cytokine release.
Its activation has been associated with various diseases, including autoimmune disorders, infections, and neuroinflammatory conditions. By understanding the role of P2X purinoceptor 7 in immune regulation, researchers can uncover new insights into disease mechanisms and potentially identify novel therapeutic targets for intervention. The CAB10511 antibody provides a reliable tool for investigating the function and expression of P2X purinoceptor 7, paving the way for advancements in the treatment of immune-related disorders.
Product Name:
P2RX7 Rabbit Polyclonal Antibody
SKU:
CAB10511
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 47-334 of human P2RX7 (NP_002553.3).
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.
Purification Method:
Affinity purification
Gene ID:
5027
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat lung, using P2RX7 antibody (CAB10511) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
