The P2RX3 Polyclonal Antibody (CAB12965) is a crucial tool for researchers studying the P2RX3 receptor, a member of the purinergic P2X receptor family involved in sensing extracellular ATP and mediating pain perception. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting P2RX3 in human samples, making it suitable for various research applications, including Western blot analysis.The P2RX3 receptor plays a vital role in nociceptive signaling, particularly in the peripheral nervous system, making it a key target in pain research. By targeting the P2RX3 receptor, researchers can gain insights into pain mechanisms and potentially develop novel therapeutic strategies for pain management.
The P2RX3 Polyclonal Antibody enables precise detection and analysis of P2RX3 expression in different cell types, offering valuable information for studies in neuroscience, pain biology, and drug development.Overall, the P2RX3 Polyclonal Antibody is a valuable tool for researchers interested in understanding the role of the P2RX3 receptor in pain signaling and exploring its potential as a target for pain relief therapies. Its high specificity and reliability make it a robust choice for investigating the functions and regulatory mechanisms of the P2RX3 receptor in various biological contexts.
Product Name:
P2RX3 Rabbit Polyclonal Antibody
SKU:
CAB12965
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 328-397 of human P2RX3 (NP_002550.2).
This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia.
Purification Method:
Affinity purification
Gene ID:
5024
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using P2RX3 Rabbit pAb (CAB12965) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
