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p19ARF Polyclonal Antibody

SKU:
CAB24462
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

p19ARF Polyclonal Antibody (CAB24462)

The p19ARF Polyclonal Antibody is a valuable tool for researchers studying the p19ARF protein, a key player in cell cycle regulation and tumor suppression. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. By binding to the p19ARF protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cancer biology and cell signaling pathways.The p19ARF protein is known for its role in inhibiting cell proliferation and inducing cell cycle arrest, making it a crucial component in preventing tumor formation.

Understanding the mechanisms through which p19ARF functions can provide valuable insights into cancer development and potentially lead to the development of new therapeutic strategies. By utilizing the p19ARF Polyclonal Antibody, researchers can delve deeper into the complex interactions of this protein and its impact on cellular processes.

Product Name:p19ARF Polyclonal Antibody
Product Code:CAB24462
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293F

Enables MDM2/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of cellular protein metabolic process; negative regulation of mammary gland epithelial cell proliferation; and positive regulation of apoptotic process involved in mammary gland involution. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A).

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse p19ARF (NP_034007.1).
Sequence:MGRRF LVTVR IQRAG RPLQE RVFLV KFVRS RRPRT ASCAL AFVNM LLRLE RILRR GPHRN PGPGD DDGQR SRSSS SAQLR CRFEL RGPHY LLPPG ARRSA
Synonyms:Arf, p16, MTS1, Pctr1, p19ARF, p16INK4a, p19, ARF-INK4a, INK4a-ARF, Ink4a/Arf, p16(INK4a)
Calculated MW:19kDa
Observed MW:17kDa

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