p16 INK4A Polyclonal Antibody (CAB23882)
- SKU:
- CAB23882
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
p16 INK4A Polyclonal Antibody (CAB23882)
The p16 INK4a Polyclonal Antibody is a crucial tool for researchers studying the p16 INK4a protein, a key player in cell cycle regulation and cellular senescence. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.p16 INK4a, also known as cyclin-dependent kinase inhibitor 2A, is a tumor suppressor protein that regulates cell proliferation by inhibiting cyclin-dependent kinases. Dysregulation of p16 INK4a has been linked to various cancers, making it a critical target for cancer research.
This antibody allows for the detection and analysis of p16 INK4a in different cell types, providing valuable insights into its role in cancer development and progression.By understanding the function of p16 INK4a, researchers can potentially develop targeted therapies for cancer treatment, as well as gain insights into cellular senescence and aging processes. This antibody is an essential tool for investigating the mechanisms underlying these biological processes and expanding our knowledge of cancer biology.
| Product Name: | p16 INK4A Polyclonal Antibody |
| Product Code: | CAB23882 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Rat spleen (six month) |
Enables MDM2/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of cellular protein metabolic process; negative regulation of mammary gland epithelial cell proliferation; and positive regulation of apoptotic process involved in mammary gland involution. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A).
| Immunogen: | Recombinant protein of mouse p16 INK4A. |
| Sequence: | Email for sequence |
| Synonyms: | Arf, p16, MTS1, Pctr1, p19ARF, p16INK4a, p19, ARF-INK4a, INK4a-ARF, Ink4a/Arf, p16(INK4a) |
| Calculated MW: | 17KDa |
| Observed MW: | 14kDa |
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