P Glycoprotein Rabbit Monoclonal Antibody (CAB19093)
The P-Glycoprotein Rabbit Monoclonal Antibody (CAB19093) is a cutting-edge tool for research involving P-Glycoprotein, a key protein involved in multidrug resistance in cancer cells. This high-quality antibody, developed using advanced monoclonal antibody technology, specifically targets P-Glycoprotein and is highly reactive with human samples. Validated for use in various applications, including Western blot and immunohistochemistry, this antibody enables accurate detection and analysis of P-Glycoprotein in different cell types.P-Glycoprotein, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in drug efflux and resistance mechanisms in cancer cells. Its overexpression in cancer cells can lead to decreased efficacy of chemotherapy drugs, posing a significant challenge in cancer treatment.
Research into the function and regulation of P-Glycoprotein is essential for developing strategies to overcome drug resistance and improve treatment outcomes for cancer patients.By using the P-Glycoprotein Rabbit Monoclonal Antibody (CAB19093) in your research, you can gain valuable insights into the role of P-Glycoprotein in cancer multidrug resistance and potentially identify new therapeutic targets for improving cancer treatment. This antibody is a valuable tool for researchers in the fields of oncology, pharmacology, and drug resistance mechanisms.
Product Name:
P Glycoprotein Rabbit Monoclonal Antibody
SKU:
CAB19093
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 393-710 of human P Glycoprotein (P08183).
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; p-170; P Glycoprotein
Positive Sample:
HepG2,Mouse brain,Mouse liver,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Multi-pass membrane protein.
Calculated MW:
141kDa
Observed MW:
130-180kDa
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5243
Clone Number:
ARC0470
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using P Glycoprotein Rabbit mAb (CAB19093) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
