P Glycoprotein Rabbit Monoclonal Antibody (CAB19093)
- SKU:
- CAB19093
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | P Glycoprotein Rabbit Monoclonal Antibody |
SKU: | CAB19093 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 393-710 of human P Glycoprotein (P08183). |
Sequence: | EFRN VHFS YPSR KEVK ILKG LNLK VQSG QTVA LVGN SGCG KSTT VQLM QRLY DPTE GMVS VDGQ DIRT INVR FLRE IIGV VSQE PVLF ATTI AENI RYGR ENVT MDEI EKAV KEAN AYDF IMKL PHKF DTLV GERG AQLS GGQK QRIA IARA LVRN PKIL LLDE ATSA LDTE SEAV VQVA LDKA RKGR TTIV IAHR LSTV RNAD VIAG FDDG VIVE KGNH DELM KEKG IYFK LVTM QTAG NEVE LENA ADES KSEI DALE MSSN DSRS SLIR KRST RRSV RGSQ AQDR KLST KEAL DESI PPVS FWRI MKLN LTEW PY |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170; p-170; P Glycoprotein |
Positive Sample: | HepG2,Mouse brain,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 141kDa |
Observed MW: | 130-180kDa |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5243 |
Clone Number: | ARC0470 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |