The OTX2 Rabbit Monoclonal Antibody (CAB4351) is a cutting-edge research tool designed for studies involving the OTX2 protein, a transcription factor known for its role in brain development and eye formation. This high-quality antibody, produced in rabbits, exhibits exceptional reactivity with human samples and has been rigorously validated for use in applications such as Western blotting and immunofluorescence.OTX2 is a key regulator of neural development, controlling processes such as neuronal differentiation and patterning in the brain. Dysregulation of OTX2 has been linked to various neurological disorders and brain tumors, emphasizing the importance of studying its function in both normal and pathological conditions.
The OTX2 Rabbit Monoclonal Antibody enables precise detection and analysis of OTX2 protein expression in different cell types, making it an invaluable tool for researchers in neuroscience and developmental biology.By elucidating the mechanisms by which OTX2 influences neural development and function, researchers can gain insights into potential therapeutic strategies for neurological disorders and brain tumors. The OTX2 Rabbit Monoclonal Antibody provides a reliable means to explore the intricate role of OTX2 in brain development and disease, paving the way for advancements in neuroscience research.
Product Name:
OTX2 Rabbit Monoclonal Antibody
SKU:
CAB4351
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 190-289 of human OTX2 (P32243).
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
Purification Method:
Affinity purification
Gene ID:
5015
Clone Number:
ARC0973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OTX2 Rabbit mAb (CAB4351) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
