The OTX2 Polyclonal Antibody (CAB5475) is a valuable tool for researchers studying the OTX2 protein, a transcription factor essential for the development of the brain and sensory organs. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications including Western blot and immunohistochemistry.OTX2 is known to play a crucial role in embryonic development, particularly in the formation of the forebrain and visual system. Dysregulation of OTX2 expression has been implicated in various neurological disorders and cancers, making it a promising target for further investigation.
The OTX2 Polyclonal Antibody allows for the detection and analysis of OTX2 protein levels in different cell types, providing valuable insights into its function and potential therapeutic implications.Researchers studying neurodevelopmental disorders, vision-related conditions, and brain tumors will find the OTX2 Polyclonal Antibody to be a valuable asset in their research endeavors. By understanding the role of OTX2 in these diseases, novel diagnostic and therapeutic strategies may be developed to benefit patients in the future.
Product Name:
OTX2 Rabbit Polyclonal Antibody
SKU:
CAB5475
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-280 of human OTX2 (NP_068374.1).
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
Purification Method:
Affinity purification
Gene ID:
5015
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OTX2 antibody (CAB5475) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 60s.
