The OTUD7B Polyclonal Antibody (CAB17329) is a valuable tool for researchers studying OTUD7B, a deubiquitinase enzyme involved in regulating protein degradation and cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the OTUD7B protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in molecular biology and cancer research.
OTUD7B plays a crucial role in maintaining cellular homeostasis by fine-tuning the ubiquitin-proteasome system, which controls protein degradation and turnover. Dysregulation of OTUD7B activity has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Understanding the intricate mechanisms of OTUD7B function is essential for developing targeted interventions that modulate protein stability and cellular signaling pathways in disease states.
Product Name:
OTUD7B Rabbit Polyclonal Antibody
SKU:
CAB17329
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 530-700 of human OTUD7B (NP_064590.2).
Enables Lys48-specific deubiquitinase activity and thiol-dependent deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus.
Purification Method:
Affinity purification
Gene ID:
56957
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OTUD7B Rabbit pAb (CAB17329) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
