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OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)

SKU:
CPAB0643
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT17E10AT
Applications:
WB
ELISA
FC
€149

Description

system_update_alt Datasheet

OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)

The OTUB1 Polyclonal Antibody (CPAB0643) is an essential tool for researchers studying OTUB1, a key protein involved in the regulation of immune responses and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications, allowing for the precise detection and analysis of OTUB1 in various cell types.OTUB1, also known as a deubiquitinating enzyme, plays a crucial role in the modulation of immune signaling pathways, making it a promising target for investigating diseases related to dysregulated immune responses, such as cancer and autoimmune disorders.

By understanding the function and regulation of OTUB1, researchers can gain valuable insights into the mechanisms underlying these diseases and develop targeted therapies to modulate immune responses effectively.Overall, the OTUB1 Polyclonal Antibody is a valuable tool for researchers interested in studying the intricate roles of OTUB1 in immune regulation and inflammation, providing a deeper understanding of its potential implications in various disease contexts.

Product Name:OTUB1 Antibody
Product Sku:CPAB0643
Size:5μg
Host Species:Mouse
Immunogen:Anti-human OTUB1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human OTUB1 protein 1-271 amino acids purified from Ecoli.
Clone:PAT17E10AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:OTUB1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Otubain 1 (OTUB1) belongs to the ovarian tumor (OUT) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system through its interaction with a ubiquitin protease and E3 ubiquitin ligase. OTUB1 is a highly specific ubiquitin iso-peptidase, it cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. OTUB1 is believed to work in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. OTUB1 is a hydrolase that removes conjugated ubiquitin from proteins in vitro and may therefore have a significant regulatory role in the level of protein turnover by preventing degradation. Additionally, OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered impassive to antigen re-challenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128/GRAIL, which is an essential inductor of CD4 T-cell anergy.
Synonyms:Ubiquitin thioesterase OTUB1, Otubain-1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Ubiquitin-specific-processing protease OTUB1, Deubiquitinating enzyme OTUB1, OTUB1, OTB1, OTU1, HSPC263, MGC4584, FLJ20113, FLJ40710, MGC111158.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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