The OSTM1 Polyclonal Antibody (CAB11685) is specifically designed for research involving OSTM1, a protein associated with osteopetrosis, a rare genetic disorder characterized by the inability to resorb bone. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the OSTM1 protein, this antibody enables accurate detection and analysis in various cell types, making it an excellent tool for studies in bone biology and genetic disorders.OSTM1 plays a crucial role in bone homeostasis by facilitating the resorption of bone tissue.
Mutations in the OSTM1 gene can lead to impaired bone resorption, resulting in the development of osteopetrosis. Understanding the function and regulation of OSTM1 is essential for unraveling the mechanisms underlying this disorder and developing targeted therapies to treat it. This antibody serves as a valuable resource for researchers investigating osteopetrosis, bone metabolism, and related conditions, ultimately contributing to advancements in bone health and disease treatment.
Product Name:
OSTM1 Rabbit Polyclonal Antibody
SKU:
CAB11685
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2).
Lysosome membrane, Single-pass type I membrane protein.
Calculated MW:
37kDa
Observed MW:
30-37kDa
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
Purification Method:
Affinity purification
Gene ID:
28962
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OSTM1 Rabbit pAb (CAB11685) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
