The Osteocalcin Polyclonal Antibody (CAB6205) is a valuable tool for researchers studying osteocalcin, a protein found in bone tissue that plays a key role in bone formation and regulation. This antibody, produced in rabbits, specifically targets osteocalcin and is highly reactive with human samples, making it ideal for use in Western blot applications.Osteocalcin is a marker for bone turnover and is involved in the regulation of bone mineralization, making it a crucial factor in bone health and disease. By utilizing the Osteocalcin Polyclonal Antibody, researchers can accurately detect and analyze osteocalcin levels in various cell types, providing valuable insights into bone metabolism and potential therapeutic targets for conditions such as osteoporosis and bone fractures.
With its high specificity and sensitivity, the Osteocalcin Polyclonal Antibody is a valuable tool for researchers in the fields of bone biology, endocrinology, and orthopedics. Its ability to target osteocalcin with precision makes it an essential component in studies aiming to understand the mechanisms of bone growth and remodeling, ultimately contributing to the development of novel therapeutic approaches for skeletal disorders.
Product Name:
BGLAP Rabbit Polyclonal Antibody
SKU:
CAB6205
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Osteocalcin (BGLAP) (NP_954642.1).
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
Purification Method:
Affinity purification
Gene ID:
632
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from U-87MG cells, using Osteocalcin (BGLAP) Rabbit pAb (CAB6205) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
