The OSM Polyclonal Antibody (PAC046598) is a valuable tool for researchers studying OSM, a cytokine involved in diverse biological processes such as inflammation, tissue regeneration, and cancer development. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.OSM, or Oncostatin M, is a member of the interleukin-6 cytokine family and plays a key role in regulating the immune response, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, including inflammatory disorders and cancer.
The OSM Polyclonal Antibody binds specifically to OSM protein, allowing for its detection and analysis in a variety of cell types, making it an essential tool for research in immunology and oncology.By understanding the role of OSM in disease pathology, researchers can develop targeted therapies that modulate its activity, leading to potential advancements in the treatment of inflammatory diseases and cancers. The OSM Polyclonal Antibody provides a reliable means to investigate the function and expression of OSM in disease models, furthering our understanding of its biological significance.
Immunofluorescent analysis of HepG2 cells using PACO46598 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Synonyms:
Oncostatin-M (OSM), Osm
UniProt Protein Function:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
NCBI Summary:
mouse homolog is a cytokine and an immediate early gene [RGD, Feb 2006]
