The OSGIN1 Polyclonal Antibody (CAB15826) is a valuable tool for researchers studying OSGIN1, a protein involved in oxidative stress response and cell death pathways. This antibody, raised in rabbits, is specifically reactive with human samples and has been validated for use in Western blot applications. By binding to the OSGIN1 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for studies in cell biology and cancer research.
OSGIN1, also known as oxidative stress-induced growth inhibitor 1, plays a crucial role in regulating cellular responses to oxidative stress, DNA damage, and apoptosis. Its function in these pathways makes it a key target for research into diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the role of OSGIN1 in cellular stress responses is important for developing therapies that target these pathways for the treatment of various diseases.
Product Name:
OSGIN1 Rabbit Polyclonal Antibody
SKU:
CAB15826
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human OSGIN1 (NP_892026.1).
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product.
Purification Method:
Affinity purification
Gene ID:
29948
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using OSGIN1 Rabbit pAb (CAB15826) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
