The OSGEP Polyclonal Antibody (CAB7473) is a critical tool for researchers studying OSGEP, a protein involved in tRNA modification and essential for cellular function. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it ideal for Western blot applications.OSGEP, or O-sialoglycoprotein endopeptidase, is a key player in the biosynthesis of wybutosine, a modified nucleoside found in tRNAs. Dysregulation of OSGEP has been linked to neurological disorders and intellectual disabilities, highlighting its importance in cellular processes.By targeting the OSGEP protein, researchers can gain valuable insights into its function and role in disease pathogenesis.
This antibody enables the detection and analysis of OSGEP in various cell types, making it a valuable tool for studies in molecular biology, neurology, and genetics.Understanding the function of OSGEP is essential for unraveling its role in disease development and progression. The OSGEP Polyclonal Antibody provides a reliable and specific means of investigating OSGEP, paving the way for new discoveries and potential therapeutic interventions in related disorders.
Product Name:
OSGEP Rabbit Polyclonal Antibody
SKU:
CAB7473
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-335 of human OSGEP (NP_060277.1).
Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3.
Purification Method:
Affinity purification
Gene ID:
55644
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OSGEP antibody (CAB7473) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
