The OSBPL2 Polyclonal Antibody (CAB14199) is a valuable tool for researchers studying OSBPL2, a protein involved in intracellular lipid transport and metabolism. This antibody, generated in rabbits, is highly specific to OSBPL2 and has been validated for use in various applications, such as Western blotting and immunofluorescence.OSBPL2, also known as oxysterol-binding protein-related protein 2, plays a key role in lipid homeostasis and intracellular cholesterol trafficking. Dysregulation of OSBPL2 has been linked to diseases like atherosclerosis, metabolic disorders, and neurodegenerative diseases.
By using the OSBPL2 Polyclonal Antibody, researchers can investigate the localization and function of OSBPL2 in different cell types and tissues, providing insights into its role in health and disease.Overall, the OSBPL2 Polyclonal Antibody is a valuable tool for advancing research in lipid biology, cellular metabolism, and related fields, offering reliable and specific detection of OSBPL2 for a wide range of experimental applications.
Product Name:
OSBPL2 Rabbit Polyclonal Antibody
SKU:
CAB14199
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 291-480 of human OSBPL2 (NP_653081.1).
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
9885
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OSBPL2 Rabbit pAb (CAB14199) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
