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ORF1 Antibody (PACO34358)

SKU:
PACO34358
Product Type:
Antibody
Reactivity:
Virus - Hepatitis E
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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ORF1 Antibody (PACO34358)

The ORF1 Antibody (PACO34358) is a valuable tool for researchers studying ORF1, a key protein in the replication and transcription of RNA viruses. This polyclonal antibody, raised in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples. By binding to the ORF1 protein, this antibody enables accurate detection and analysis of ORF1 in various cell types, making it ideal for investigations in virology and infectious disease research.

ORF1 is essential for viral replication and is a potential target for antiviral drug development. Understanding the role of ORF1 in viral infection is crucial for developing strategies to combat RNA viruses such as coronaviruses, retroviruses, and flaviviruses. The ORF1 Antibody (PACO34358) provides researchers with a reliable tool for studying the function and expression of ORF1, advancing our knowledge of viral biology and aiding in the development of novel therapeutics.

Antibody Name:ORF1 Antibody (PACO34358)
Antibody SKU:PACO34358
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Hepatitis E virus genotype 1
Immunogen:Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 protein (60-240AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Methyltransferase displays a cytoplasmic capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. The enzymatic reaction involves a covalent link between 7-methyl-GMP and the methyltransferase, whereas eukaryotic capping enzymes form a covalent complex only with GMP. Methyltransferase catalyzes transfer of a methyl group from S-adenosylmethionine to GTP and GDP to yield m7GTP or m7GDP. GMP, GpppG, and GpppA were poor substrates for the methyltransferase. This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m7GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure. Cap analogs such as m7GTP, m7GDP, et2m7GMP, and m2et7GMP inhibit the methyltransferase reaction (By similarity).
Synonyms:Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative papain-like cysteine protease (PLP) (EC 3.4.22.-); NTPase/helicase (EC 3.6.4.-); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48)]
UniProt Protein Function:Methyltransferase displays a cytoplasmic capping enzyme activity. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. The enzymatic reaction involves a covalent link between 7-methyl-GMP and the methyltransferase, whereas eukaryotic capping enzymes form a covalent complex only with GMP. Methyltransferase catalyzes transfer of a methyl group from S-adenosylmethionine to GTP and GDP to yield m7GTP or m7GDP. GMP, GpppG, and GpppA were poor substrates for the methyltransferase. This enzyme also displays guanylyltransferase activity to form a covalent complex, methyltransferase-m7GMP, from which 7-methyl-GMP is transferred to the mRNA to create the cap structure. Cap analogs such as m7GTP, m7GDP, et2m7GMP, and m2et7GMP inhibit the methyltransferase reaction ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:P33424
NCBI GenInfo Identifier:4033773
NCBI Gene ID:
NCBI Accession:P33424.2
UniProt Secondary Accession:P33424,Q8UYD6
UniProt Related Accession:P33424
Molecular Weight:24.4 kDa
NCBI Full Name:Non-structural polyprotein pORF1
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Non-structural polyprotein pORF1
UniProt Synonym Protein Names:
Protein Family:Protein
UniProt Gene Name:ORF1  
UniProt Entry Name:POLN_HEVPA

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