The Orc6 Polyclonal Antibody (CAB7966) is specifically designed for research involving Orc6, a key protein involved in the formation of the origin recognition complex (ORC) during DNA replication. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.Orc6 is essential for the initiation of DNA replication and plays a crucial role in maintaining genomic stability. Dysregulation of Orc6 has been linked to various diseases, including cancer and genetic disorders.
Therefore, studying Orc6 and its functions is important for understanding the mechanisms of DNA replication and its implications in disease development.By using the Orc6 Polyclonal Antibody, researchers can effectively detect and analyze Orc6 protein levels in various cell types, providing valuable insights into the processes of DNA replication and potential therapeutic targets for diseases associated with Orc6 dysregulation. This antibody is a valuable tool for studies in molecular biology, genetics, and cancer research.
Product Name:
ORC6 Rabbit Polyclonal Antibody
SKU:
CAB7966
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human ORC6 (NP_055136.1).
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Purification Method:
Affinity purification
Gene ID:
23594
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ORC6 antibody (CAB7966) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (AbGn00020)._Exposure time: 30s.
