ORC6 Rabbit Polyclonal Antibody (CAB5426)
- SKU:
- CAB5426
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | ORC6 Rabbit Polyclonal Antibody |
SKU: | CAB5426 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human ORC6 (NP_055136.1). |
Sequence: | MGSE LIGR LAPR LGLA EPDM LRKA EEYL RLSR VKCV GLSA RTTE TSSA VMCL DLAA SWMK CPLD RAYL IKLS GLNK ETYQ SCLK SFEC LLGL NSNI GIRD LAVQ FSCI EAVN MASK ILKS YESS LPQT QQVD LDLS RPLF TSAA LLSA CKIL KLKV DKNK MVAT SGVK KAIF DRLC KQLE KIGQ QVDR EPGD VATP PRKR KKIV VEAP AKEM EKVE EMPH KPQK DEDL TQDY EEWK RKIL ENAA SAQK ATAE |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | ORC6L; ORC6 |
Positive Sample: | Jurkat,SW620,PC-3,HeLa,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Purification Method: | Affinity purification |
Gene ID: | 23594 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |