The ORC6 Polyclonal Antibody (CAB5426) is a valuable tool for researchers studying the ORC6 protein, a key component of the Origin Recognition Complex involved in DNA replication. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it an excellent choice for Western blot applications.ORC6 plays a pivotal role in ensuring the accurate initiation of DNA replication, making it essential for cell division and growth. Dysregulation of ORC6 has been linked to various diseases, including cancer, making it an attractive target for research into cancer biology and potential therapeutic interventions.
By using the ORC6 Polyclonal Antibody, researchers can detect and analyze ORC6 expression in different cell types, shedding light on its function and potential implications in disease development. This antibody is a valuable tool for studies in molecular biology, genetics, and cancer research, offering insights into the complex mechanisms underlying DNA replication and cell proliferation.
Product Name:
ORC6 Rabbit Polyclonal Antibody
SKU:
CAB5426
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human ORC6 (NP_055136.1).
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
Purification Method:
Affinity purification
Gene ID:
23594
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ORC6 Rabbit pAb (CAB5426) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
