The ORC3 Polyclonal Antibody (CAB15415) is a vital tool for researchers studying ORC3, a key protein involved in DNA replication and cell division. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot experiments. By binding specifically to the ORC3 protein, this antibody allows for precise and accurate detection and analysis in a variety of cell types.ORC3, part of the Origin Recognition Complex, is essential for the initiation of DNA replication and the maintenance of genomic stability. Dysregulation of ORC3 has been linked to various diseases, including cancer, developmental disorders, and neurodegenerative conditions.
By understanding the function and regulation of ORC3, researchers can gain valuable insights into cellular processes and potentially uncover new therapeutic targets for these diseases.With its specificity and reliability, the ORC3 Polyclonal Antibody is an excellent tool for immunology, cancer research, and studies related to DNA replication and cell division. Its application extends to a wide range of research areas, making it an invaluable resource for scientists studying the intricate mechanisms of cellular biology.
Product Name:
ORC3 Rabbit Polyclonal Antibody
SKU:
CAB15415
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ORC3 (NP_036513.2).
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
23595
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ORC3 Rabbit pAb (CAB15415) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
