ORC2 Rabbit Polyclonal Antibody (CAB15697)
- SKU:
- CAB15697
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ORC2 Rabbit Polyclonal Antibody |
SKU: | CAB15697 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-577 of human ORC2 (NP_006181.1). |
Sequence: | TSYE NSLL VKQS GSLP LSSL THVL RSLT PNAR GIFR LLIK YQLD NQDN PSYI GLSF QDFY QQCR EAFL VNSD LTLR AQLT EFRD HKLI RTKK GTDG VEYL LIPV DNGT LTDF LEKE EEEA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ORC2L; ORC2 |
Positive Sample: | HeLa,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 66kDa |
Observed MW: | 80kDa |
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.
Purification Method: | Affinity purification |
Gene ID: | 4999 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |