ORC1 Rabbit Polyclonal Antibody (CAB14756)
- SKU:
- CAB14756
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ORC1 Rabbit Polyclonal Antibody |
SKU: | CAB14756 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 696-856 of human ORC1 (NP_001177748.1). |
Sequence: | EDDA IQLV ARKV AALS GDAR RCLD ICRR ATEI CEFS QQKP DSPG LVTI AHSM EAVD EMFS SSYI TAIK NSSV LEQS FLRA ILAE FRRS GLEE ATFQ QIYS QHVA LCRM EGLP YPTM SETM AVCS HLGS CRLL LVEP SRND LLLR VRLN VSQD DVLY ALKD E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ORC1L; PARC1; HSORC1; ORC1 |
Positive Sample: | HeLa,293T,A-431,K-562,Jurkat,MCF7,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 97kDa |
Observed MW: | 90kDa |
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4998 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |