The ORAI1 Polyclonal Antibody (CAB7412) is a valuable tool for researchers studying ORAI1, a key protein involved in calcium signaling and immune response regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the ORAI1 protein, this antibody enables accurate detection and analysis in various cell types, providing valuable insights into the role of ORAI1 in immunology and cancer research.ORAI1 is a crucial component of calcium release-activated calcium (CRAC) channels, which play a vital role in immune cell activation and cytokine production.
Dysregulation of ORAI1 has been linked to various immune-related disorders, including autoimmune diseases and cancer. Research on ORAI1 is essential for understanding the mechanisms underlying these diseases and for developing targeted therapies to modulate immune responses effectively.Overall, the ORAI1 Polyclonal Antibody (CAB7412) serves as a reliable tool for investigating the function and regulation of ORAI1 in different cellular contexts, making it a valuable resource for researchers in the fields of immunology and cancer biology.
Product Name:
ORAI1 Rabbit Polyclonal Antibody
SKU:
CAB7412
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ORAI1 (NP_116179.2).
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).
Purification Method:
Affinity purification
Gene ID:
84876
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using (CAB7412) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
