OPTN Rabbit Polyclonal Antibody (CAB1845)
- SKU:
- CAB1845
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Autophagy
Frequently bought together:
Description
Product Name: | OPTN Rabbit Polyclonal Antibody |
SKU: | CAB1845 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP_068815.2). |
Sequence: | MSHQ PLSC LTEK EDSP SEST GNGP PHLA HPNL DTFT PEEL LQQM KELL TENH QLKE AMKL NNQA MKGR FEEL SAWT EKQK EERQ FFEI QSKE AKER LMAL SHEN EKLK EELG KLKG KSER SSED PTDD SRLP RAEA EQEK DQLR TQVV RLQA EKAD LLGI VSEL QLKL NSSG SSED SFVE IRMA EGEA EGSV KEIK HSPG PTRT VSTG TALS KYRS RSAD GAKN YFEH EELT VSQL LLCL REGN QKVE RLEV ALKE AKER VSDF EKKT SNRS EIET QTEG STEK ENDE EKGP ETVG SEVE ALNL QVTS LFKE LQEA HTKL SEAE LMKK RLQE KCQA LERK NSAI PSEL NEKQ ELVY TNKK LELQ VESM LSEI KMEQ AKTE DEKS KLTV LQMT HNKL LQEH NNAL KTIE ELTR KESE KVDR AVLK ELSE KLEL AEKA LASK QLQM DEMK QTIA KQEE DLET MTIL RAQM EVYC SDFH AERA AREK IHEE KEQL ALQL AVLL KEND AFED GGRQ SLME MQSR HGAR TSDS DQQA YLVQ RGAE DRDW RQQR NIPI HSCP KCGE VLPD IDTL QIHV MDCI I |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 25μg-100μg extracts of whole cells |
Synonyms: | NRP; FIP2; HIP7; HYPL; ALS12; GLC1E; TFIIIA-INTP; OPTN |
Positive Sample: | HeLa,OVCAR3,A-549,Mouse liver,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Recycling endosome, autophagosome, perinuclear region, trans-Golgi network. |
Calculated MW: | 66kDa |
Observed MW: | 78kDa |
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method: | Affinity purification |
Gene ID: | 10133 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |