The OPRM1 Polyclonal Antibody (CAB16939) is a valuable tool for researchers studying the Opioid Receptor Mu 1 (OPRM1) protein, which plays a key role in mediating the effects of opioids in the body. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications.OPRM1 is a G protein-coupled receptor that binds to endogenous opioids and opiate drugs, regulating pain perception, reward pathways, and mood. Dysregulation of OPRM1 has been linked to opioid addiction, chronic pain conditions, and mental health disorders.
By targeting OPRM1 with this antibody, researchers can gain insights into its expression levels and localization in various cell types, advancing our understanding of opioid signaling and potential therapeutic strategies.With its ability to detect and analyze OPRM1 protein, the CAB16939 antibody is a valuable tool for investigations in pharmacology, neuroscience, and addiction research. By elucidating the role of OPRM1 in opioid-related disorders, researchers can pave the way for novel interventions and personalized treatment approaches in the field of pain management and substance abuse.
Product Name:
OPRM1 Rabbit Polyclonal Antibody
SKU:
CAB16939
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 354-388 of human Mu Opioid Receptor(MOR) (NP_000905.3).
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
Purification Method:
Affinity purification
Gene ID:
4988
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Mu Opioid Receptor(MOR) Rabbit pAb (CAB16939) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
