OPRL1 Rabbit Polyclonal Antibody (CAB3113)
- SKU:
- CAB3113
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Product Name: | OPRL1 Rabbit Polyclonal Antibody |
SKU: | CAB3113 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 270-370 of human OPRL1 (NP_000904.1) |
Sequence: | AVFV GCWT PVQV FVLA QGLG VQPS SETA VAIL RFCT ALGY VNSC LNPI LYAF LDEN FKAC FRKF CCAS ALRR DVQV SDRV RSIA KDVA LACK TSET VPRP A |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; PNOCR; OPRL1 |
Positive Sample: | K-562,SW620,NCI-H460,U-87MG |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein. |
Calculated MW: | 41kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Purification Method: | Affinity purification |
Gene ID: | 4987 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |