The Nociceptin Receptor Polyclonal Antibody (CAB3113) is a powerful tool for researchers studying nociceptin receptors, which play a key role in pain perception and modulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications. By targeting the nociceptin receptor protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component in studies related to pain signaling, neurobiology, and drug development.
Nociceptin receptors, also known as ORL-1 receptors, are involved in regulating pain sensitivity and the body's response to painful stimuli. Understanding the function and signaling pathways of these receptors is crucial for developing effective pain management strategies and novel therapeutics for chronic pain conditions. The Nociceptin Receptor Polyclonal Antibody provides researchers with a reliable tool for investigating nociceptin receptor biology and its implications in pain-related disorders.
Product Name:
OPRL1 Rabbit Polyclonal Antibody
SKU:
CAB3113
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 270-370 of human OPRL1 (NP_000904.1)
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Purification Method:
Affinity purification
Gene ID:
4987
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OPRL1 antibody (CAB3113) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).
