OPN4 Rabbit Polyclonal Antibody (CAB16289)
- SKU:
- CAB16289
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | OPN4 Rabbit Polyclonal Antibody |
SKU: | CAB16289 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 365-489 of human OPN4 (NP_001025186.1). |
Sequence: | HPKY RVAI AQHL PCLG VLLG VSRR HSRP YPSY RSTH RSTL TSHT SNLS WISI RRRQ ESLG SESE VGWT HMEA AAVW GAAQ QANG RSLY GQGL EDLE AKAP PRPQ GHEA ETPG KTKG LIPS QDPR M |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | MOP; OPN4 |
Positive Sample: | U-251MG |
Conjugate: | Unconjugated |
Cellular Localization: | axon, dendrite, perikaryon, plasma membrane |
Calculated MW: | 53kDa |
Observed MW: | 53kDa |
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 94233 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |