The OPA3 Polyclonal Antibody (CAB7997) is a valuable tool for researchers studying OPA3, a protein involved in mitochondrial function and metabolism. This antibody, generated in rabbits, is highly specific for OPA3 in human samples and has been validated for use in Western blot applications. By binding to OPA3, the antibody enables researchers to detect and analyze the protein in various cell types, making it ideal for studies in mitochondrial biology and related diseases.OPA3 plays a critical role in maintaining mitochondrial morphology and function, making it a target of interest in research on mitochondrial dynamics and metabolism.
Dysregulation of OPA3 has been associated with mitochondrial dysfunction and neurodegenerative disorders, making it a key player in understanding the pathogenesis of these diseases. By studying OPA3, researchers can gain insights into how mitochondrial dysfunction contributes to disease development and potentially uncover new therapeutic targets for treatment.
Product Name:
OPA3 Rabbit Polyclonal Antibody
SKU:
CAB7997
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-179 of human OPA3 (NP_079412.1).
The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
80207
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OPA3 antibody (CAB7997) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
