The OPA1 Polyclonal Antibody (CAB9833) is a valuable tool for researchers studying the OPA1 protein, an essential component of mitochondrial fusion and regulation of cell apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to OPA1, this antibody allows for precise detection and analysis of the protein in various cell types, making it a versatile option for studies in mitochondrial biology and related diseases.OPA1, also known as optic atrophy 1 protein, plays a crucial role in maintaining mitochondrial function and integrity.
Dysregulation of OPA1 has been implicated in various diseases, including optic atrophy, neurodegenerative disorders, and metabolic syndromes. Understanding the function of OPA1 is essential for investigating the underlying mechanisms of these conditions and developing targeted therapies to restore mitochondrial health.Overall, the OPA1 Polyclonal Antibody (CAB9833) offers researchers a reliable tool for studying the intricate roles of OPA1 in mitochondrial dynamics and cellular homeostasis, providing valuable insights into diseases associated with mitochondrial dysfunction.
Product Name:
OPA1 Rabbit Polyclonal Antibody
SKU:
CAB9833
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-600 of human OPA1 (NP_056375.2).
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness.
Purification Method:
Affinity purification
Gene ID:
4976
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using OPA1 antibody (CAB9833) at 1:7000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
