The OLR1 Polyclonal Antibody (CAB1639) is a vital tool for researchers studying the OLR1 receptor, also known as oxidized low-density lipoprotein receptor 1. This cell surface receptor is involved in lipid metabolism, inflammation, and atherosclerosis, making it a key target in cardiovascular research.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the OLR1 protein, allowing for accurate detection and analysis in a variety of cell types. This makes it an ideal choice for studies in cardiovascular disease, lipid metabolism, and related research areas.
The OLR1 receptor has been implicated in various cardiovascular conditions, including atherosclerosis, which is a leading cause of heart disease. Understanding the role of OLR1 in lipid uptake and inflammation is crucial for developing new therapies to combat these diseases and improve patient outcomes.By using the OLR1 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying cardiovascular diseases and potentially identify new targets for drug development. Its high specificity and reliability make it a valuable tool for advancing our understanding of OLR1 biology and its implications for human health.
Product Name:
OLR1 Rabbit Polyclonal Antibody
SKU:
CAB1639
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 58-273 of human OLR1 (NP_002534.1).
Cell membrane, Lipid-anchor, Membrane raft, Secreted, Single-pass type II membrane protein.
Calculated MW:
31kDa
Observed MW:
31kDa
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using OLR1 antibody (CAB1639) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
