The OLR1 Polyclonal Antibody (CAB12060) is a valuable tool for researchers studying OLR1, a protein involved in lipid metabolism and inflammation regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the OLR1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cardiovascular disease, atherosclerosis, and metabolic disorders.OLR1, also known as oxidized low-density lipoprotein receptor 1, plays a crucial role in lipid uptake and transport, as well as in inflammatory responses triggered by oxidized lipids.
Dysregulation of OLR1 has been implicated in the development of cardiovascular diseases, making it a promising target for therapeutic interventions. Research on OLR1 function and regulation is essential for developing strategies to mitigate the detrimental effects of lipid accumulation and inflammation in cardiovascular health.Overall, the OLR1 Polyclonal Antibody (CAB12060) provides researchers with a reliable tool for investigating the role of OLR1 in lipid metabolism, inflammation, and cardiovascular disease, ultimately contributing to the development of innovative therapeutic approaches in these areas.
Product Name:
OLR1 Rabbit Polyclonal Antibody
SKU:
CAB12060
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human OLR1 (NP_002534.1).
Cell membrane, Lipid-anchor, Membrane raft, Secreted, Single-pass type II membrane protein.
Calculated MW:
31kDa
Observed MW:
31kDa
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4973
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse lung, using OLR1 Rabbit pAb (CAB12060) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
