The Olig2 Polyclonal Antibody (CAB12814) is a valuable tool for researchers studying Olig2, a transcription factor crucial for the development of motor neurons in the central nervous system. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in techniques such as Western blotting.Olig2 is a key player in the regulation of neural progenitor cells and is involved in various neurological disorders and brain tumors.
By targeting Olig2 with this antibody, researchers can detect and analyze the expression of this protein in different cell types, providing insights into its role in neurodevelopment and disease pathology. This antibody is an essential tool for studies in neuroscience, neurology, and oncology, offering new avenues for understanding and potentially treating conditions related to Olig2 dysregulation.
Product Name:
Olig2 Rabbit Polyclonal Antibody
SKU:
CAB12814
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-80 of human Olig2 (NP_005797.1).
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.
Purification Method:
Affinity purification
Gene ID:
10215
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Olig2 Rabbit pAb (CAB12814) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
