OGG1 Rabbit Monoclonal Antibody (CAB4997)
- SKU:
- CAB4997
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HMMH
- HOGG1
- MUTM
- OGH1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | OGG1 Rabbit Monoclonal Antibody |
SKU: | CAB4997 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 246-345 of human OGG1 (O15527). |
Sequence: | VGTK VADC ICLM ALDK PQAV PVDV HMWH IAQR DYSW HPTT SQAK GPSP QTNK ELGN FFRS LWGP YAGW AQAV LFSA DLRQ SRHA QEPP AKRR KGSK GPEG |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | HMMH; MUTM; OGH1; HOGG1; OGG1 |
Positive Sample: | HeLa,HT-29,U-251MG,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion, Nucleus, Nucleus matrix, Nucleus speckle, nucleoplasm. |
Calculated MW: | 39kDa |
Observed MW: | 39kDa |
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 4968 |
Clone Number: | ARC1233 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |