The OGG1 Polyclonal Antibody (CAB2268) is a valuable tool for research involving the OGG1 protein, which plays a crucial role in DNA repair and maintenance. The antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the OGG1 protein, this antibody enables researchers to detect and analyze OGG1 expression in various cell types, making it ideal for studies in genetics, cancer research, and aging-related diseases.
OGG1, also known as 8-oxoguanine DNA glycosylase, is an essential enzyme involved in the repair of DNA damage caused by oxidative stress. Mutations in the OGG1 gene have been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Research on OGG1 function and regulation is crucial for understanding the mechanisms underlying these conditions and for developing potential treatments and interventions.
Product Name:
OGG1 Rabbit Polyclonal Antibody
SKU:
CAB2268
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1).
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Purification Method:
Affinity purification
Gene ID:
4968
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using OGG1 Rabbit pAb (CAB2268) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
