OGG1 Rabbit Polyclonal Antibody (CAB2268)
- SKU:
- CAB2268
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | OGG1 Rabbit Polyclonal Antibody |
SKU: | CAB2268 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1). |
Sequence: | MPAR ALLP RRMG HRTL ASTP ALWA SIPC PRSE LRLD LVLP SGQS FRWR EQSP AHWS GVLA DQVW TLTQ TEEQ LHCT VYRG DKSQ ASRP TPDE LEAV RKYF QLDV TLAQ LYHH WGSV DSHF QEVA QKFQ GVRL LRQD PIEC LFSF ICSS NNNI ARIT GMVE RLCQ AFGP RLIQ LDDV TYHG FPSL QALA GPEV EAHL RKLG LGYR ARYV SASA RAIL EEQG GLAW LQQL RESS YEEA HKAL CILP GVGT KVAD CICL MALD KPQA VPVD VHMW HIAQ RDYS WHPT TSQA KGPS PQTN KELG NFFR SLWG PYAG WAQA VLFS ADLR QSRH AQEP PAKR RKGS KGPE G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 |
Synonyms: | HMMH; MUTM; OGH1; HOGG1; OGG1 |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion, Nucleus, Nucleus matrix, Nucleus speckle, nucleoplasm. |
Calculated MW: | 39kDa |
Observed MW: | 36kDa |
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 4968 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |