The OGG1 Polyclonal Antibody (CAB1384) is a vital tool for researchers studying OGG1, a DNA glycosylase enzyme involved in the repair of oxidative DNA damage. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in immunohistochemistry and Western blot applications. Through targeting the OGG1 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in the fields of DNA repair, oxidative stress, and cancer research.
OGG1 is a key player in the base excision repair pathway, where it acts to remove 8-oxoguanine, a common DNA lesion caused by reactive oxygen species. Dysregulation of OGG1 activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. By unraveling the molecular mechanisms underlying OGG1 function, researchers can gain valuable insights into the pathogenesis of these conditions and identify potential therapeutic targets for their treatment.
Product Name:
OGG1 Rabbit Polyclonal Antibody
SKU:
CAB1384
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1).
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Purification Method:
Affinity purification
Gene ID:
4968
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using OGG1 Rabbit pAb (CAB1384) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
