The OGDHL Polyclonal Antibody (CAB15475) is a vital tool for research involving OGDHL, an enzyme involved in the citric acid cycle and amino acid metabolism. This antibody, derived from rabbit antibodies, provides high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the OGDHL protein, this antibody allows for the detection and analysis of OGDHL in various cell types, making it ideal for studies in biochemistry and metabolism research.OGDHL, also known as 2-oxoglutarate dehydrogenase-like protein, plays a crucial role in the energy production process within cells and is essential for cellular metabolism.
Understanding the function and regulation of OGDHL can provide valuable insights into metabolic pathways and their dysregulation in diseases like cancer, metabolic disorders, and neurodegenerative diseases. Research on OGDHL could lead to the development of novel therapeutic strategies targeting metabolic pathways for the treatment of these conditions.
Product Name:
OGDHL Rabbit Polyclonal Antibody
SKU:
CAB15475
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human OGDHL (NP_060715.2).
The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells.
Purification Method:
Affinity purification
Gene ID:
55753
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OGDHL Rabbit pAb (CAB15475) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
