The OGDH Polyclonal Antibody (CAB6391) is a valuable tool for researchers studying OGDH, an enzyme involved in the tricarboxylic acid cycle and energy metabolism. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the OGDH protein, this antibody enables the detection and analysis of OGDH in a variety of cell types.OGDH is a key player in cellular energy production and metabolism, making it a crucial target for research in fields such as biochemistry, physiology, and disease pathology. Dysregulation of OGDH activity has been linked to various health conditions, including metabolic disorders, neurodegenerative diseases, and cancer.
By studying OGDH with this antibody, researchers can gain valuable insights into its role in cellular function and its potential as a therapeutic target.Overall, the OGDH Polyclonal Antibody (CAB6391) is a versatile tool for investigating OGDH function and its implications in health and disease. Its high reactivity and specificity make it a reliable choice for researchers seeking to deepen their understanding of cellular metabolism and explore potential treatment approaches for OGDH-related conditions.
Product Name:
OGDH Rabbit Polyclonal Antibody
SKU:
CAB6391
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human OGDH (NP_001003941.1).
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
4967
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using OGDH Rabbit pAb (CAB6391) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
