The OFD1 Polyclonal Antibody (CAB17567) is a valuable tool for research into the OFD1 protein, a key player in ciliogenesis and primary cilia formation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting OFD1 in human samples, making it a reliable choice for Western blot applications.OFD1, a centrosomal/basal body protein, is essential for normal cilia assembly and function, playing a critical role in various cellular processes such as cell division, signal transduction, and sensory perception. Dysregulation of OFD1 has been linked to ciliopathies, a group of genetic disorders characterized by cilia dysfunction.
By using the OFD1 Polyclonal Antibody, researchers can explore the function of OFD1 in different cell types and tissues, shedding light on its involvement in ciliogenesis and its potential implications in diseases associated with cilia defects. This antibody is a valuable tool for studies in developmental biology, genetics, and related fields, providing insights that may lead to new therapeutic strategies for ciliopathy-associated disorders.
Product Name:
OFD1 Rabbit Polyclonal Antibody
SKU:
CAB17567
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 763-1012 of human OFD1 (NP_003602.1).
This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome.
Purification Method:
Affinity purification
Gene ID:
8481
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using OFD1 Rabbit pAb (CAB17567) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
